She is under strict doctors' orders to limit her activity to attending rehearsals for her band's upcoming tour.
But Frankie Sandford defied her instructions tonight to make her first television performance in months in aid of Children in Need.
The 22-year-old made a sensational comeback tonight to perform their new single My Heart Takes Over with The Saturdays during the marathon fundraising show.
Comeback: Frankie Sandford defied doctors' orders tonight to perform with the Saturdays on Children in Need
All for charity: The 22-year-old has been told not to do any live performances while she recovers from a mystery illness
Although slender, she looked healthy and gorgeous as she performed with her equally glamorous band mates.
The girls all wore sequinned, floor length dresses for their performance, with Rochelle in glittering gold and Mollie in a navy dress with plunging neckline.
Glamorous: The girl band sang their new single My Heart Takes Over
Earlier in the day The Saturdays performed without Frankie on Loose Women to promote their new single.
Miss Sandford had been dubbed a 'part-time Saturday' after she was instructed by doctors to not participate in any televised performances while she recovered from a recent mystery illness.
Fighting fit: The singer looked gorgeous in a strapless silver gown
'She's easing herself back in to things with the group but will be appearing on the tour which starts at the end of this month.'
The Saturdays will be heading on their first UK arena tour this winter, beginning on December 2nd in Bournemouth and ending at London's Wembley Arena on December 16th.
Foursome: Earlier in the day The Saturdays performed without Frankie on Loose Women
Niall Horan, Zayn Malik, Liam Payne, Harry Styles and Louis Tomlinson kicked off proceedings by taking to the stage to belt out What Makes You Beautiful.
Fellow X Factor acts JLS, Olly Murs and Matt Cardle also all performed their singles alongside a number of charity acts from television presenters and stars.
New kids on the block: One Direction opened the show with a performance of What Makes You Beautiful
Four of the BBC’s female newsreaders took part in a Strictly Come Dancing Children In Need special competition.
Bruce Forsyth and Tess Daly presented the dance-off, with judges Alesha Dixon, Len Goodman, Bruno Tonioli and Craig Horwood sitting on the panel.
Showstopper: Gok Wan performs with his own razzle dazzle and backing dancers
But there could only be one winner and that title went to Susanna Reid and her partner Robin Windsor.
The next special guest who took to the stage might not be famed for his singing, but fashion guru Gok Wan put on an amazing performance of Razzle Dazzle from the musical Chicago.
Sporting a dark moustache, Gok performed alongside four scantily clad dancers for the full effect.
He said: ‘That was the scariest thing I’ve ever done. Getting women naked - easy. Getting on stage – the hardest thing ever.’
And keeping up the musical theme, the cast of EastEnders paid tribute to Queen by performing a range of hits from the British rock band.
Cast members from Hollyoaks then made their attempt at a musical performance, who were followed by Westlife performing You Raise Me Up.